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Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on‐resonance T 1 in the rotating frame
Author(s) -
Gröhn Olli H.J.,
Lukkarinen Jouko A.,
Silvennoinen M. Johanna,
Pitkänen Asla,
van Zijl Peter C.M.,
Kauppinen Risto A.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199908)42:2<268::aid-mrm8>3.0.co;2-a
Subject(s) - ischemia , magnetic resonance imaging , perfusion , nuclear magnetic resonance , occlusion , middle cerebral artery , chemistry , medicine , physics , radiology
Sensitivity of T 1 in the rotating frame (T 1ρ ) to both transient cerebral ischemia and cortical hypoperfusion was studied in rats. T 1ρ is believed to probe water in close contact with macromolecules, revealing water spins with restricted rotational mobility relative to bulk water. It is shown that T 1ρ increases within minutes of occlusion, thereby demonstrating it as a new, sensitive indicator of ischemia. After reperfusion at 90 minutes of middle cerebral artery occlusion, T 1ρ remains elevated or increases in tissue destined to neuronal damage but returns to the normal level if no neuronal damage develops within 24 hours. T 1ρ determined during the first 2 hours of reperfusion shows a significant positive correlation with the ultimate neuronal damage score. However, T 1ρ is not affected by acute hypoperfusion. These data show that, by combining three magnetic resonance imaging coefficients, i.e. T 1ρ , T 2 , and diffusion, viable hypoperfused areas that do not develop neuronal damage within 24 hours can be distinguished correctly from tissue already destined for neuronal damage. Magn Reson Med 42:268–276, 1999. © 1999 Wiley‐Liss, Inc.