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Assessment of myocardial viability using MRI during a constant infusion of Gd‐DTPA: Further studies at early and late periods of reperfusion
Author(s) -
Pereira Raoul S.,
Prato Frank S.,
Sykes Jane,
Wisenberg Gerald
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199907)42:1<60::aid-mrm10>3.0.co;2-9
Subject(s) - gadolinium , magnetic resonance imaging , reperfusion injury , myocardial infarction , nuclear medicine , in vivo , medicine , ischemia , occlusion , infarction , pentetic acid , chemistry , cardiology , radiology , chelation , microbiology and biotechnology , organic chemistry , biology
It was previously shown in a canine model of ischemia/reperfusion injury that the partition coefficient of gadolinium‐diethylene triamine pentaacetic acid (Gd‐DTPA) (λ) increases in infarcted tissue. That previous study used a non‐magnetic resonance imaging (MRI) method to measure λ and only investigated reperfusion times from 2 hr to 3 weeks. This study presents evidence suggesting that λ starts to increase as early as 1 min after reperfusion of a 2 hr occlusion and continues to rise for up to 2 hr or more; λ stays increased as late as 8 weeks, reaching peak values at 1–11 days and subsequently decreasing. It was also demonstrated that λ can be accurately measured in vivo using a saturation recovery turbo fast low‐angle shot (FLASH) sequence. The results of this study show that MRI during a constant infusion of Gd‐DTPA has great potential for the non‐invasive determination of myocardial viability as early as 1 min to as late as 8 weeks following reperfusion of acute myocardial infarction. Magn Reson Med 42:60–68, 1999. © 1999 Wiley‐Liss, Inc.