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Non‐invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI
Author(s) -
Jones Derek K.,
Simmons Andrew,
Williams Steve C.R.,
Horsfield Mark A.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199907)42:1<37::aid-mrm7>3.0.co;2-o
Subject(s) - diffusion mri , neuroscience , nuclear magnetic resonance , human brain , fiber tract , diffusion , fiber , magnetic resonance imaging , chemistry , medicine , physics , biology , radiology , organic chemistry , thermodynamics
A technique for assessing in vivo fiber connectivity in the human brain is presented. The method utilizes a novel connectivity algorithm that operates in three spatial dimensions and uses estimates of fiber tract orientation and tissue anisotropy, obtained from diffusion tensor magnetic resonance imaging, to establish the pathways of fiber tracts. Sample in vivo connectivity images from healthy human brain are presented that demonstrate connections in the white matter tracts. White matter connectivity information is potentially of interest in the study of a range of neurological, psychiatric, and developmental disorders and shows promise for following the natural history of disease. Magn Reson Med 42:37–41, 1999. © 1999 Wiley‐Liss, Inc.