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1 H chemical shift imaging of the human brain at age 60–90 years reveals metabolic differences between women and men
Author(s) -
Sijens P.E.,
Oudkerk M.,
de Leeuw F.E.,
de Groot J.C.,
Achten E.,
Heijboer R.,
Hofman A.,
Breteler M.M.B.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199907)42:1<24::aid-mrm5>3.0.co;2-3
Subject(s) - creatine , choline , metabolite , human brain , nuclear medicine , voxel , in vivo magnetic resonance spectroscopy , nuclear magnetic resonance , magnetic resonance imaging , chemistry , medicine , endocrinology , biology , physics , neuroscience , radiology
1 H magnetic resonance spectroscopy was used to compare brain metabolism in 540 elderly persons, stratified by sex and age (60–90 years old). An 8 × 8 × 2 cm 3 supraventricular brain volume, a transverse plane parallel to the canthomeatal line, was examined by automated 1 H chemical shift imaging [point‐resolved spectroscopy (PRESS), TE of 35 msec]. Regional choline (Cho), creatine (Cr), and N‐acetyl aspartate (NAA) peak areas in the 518 successful examinations (96%) were studied by division through the total area of the particular metabolite in each spectral map. This procedure eliminated intersubject variance, maximized intervoxel variance (26 ≤ F ≤ 149, P < 0.0001) and reduced the standard deviations in the voxel metabolite signals threefold. Normalized signals in women ( n = 257) and men ( n = 261) differed in 9 (Cho/ΣCho), 8 (Cr/ΣCr), and 10 (NAA/ΣNAA) of 36 voxels examined ( P ≤ 0.001). In the cingulate gyrus Cho/ΣCho, Cr/ΣCr, and NAA/ΣNAA were reduced in men compared with women. These findings are consistent with a sex‐related reduction of glucose metabolism in the same brain lobe revealed by positron emission tomography. Magn Reson Med 42:24–31, 1999. © 1999 Wiley‐Liss, Inc.