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In vivo time course studies of the tissue responses to resorbable polylactic acid implants by means of MRI
Author(s) -
Stroman Patrick W.,
Dorvil JeanClaude,
Marois Yves,
Poddevin Nicolas,
Guidoin Robert
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199907)42:1<210::aid-mrm29>3.0.co;2-q
Subject(s) - polylactic acid , in vivo , biomedical engineering , medicine , chemistry , biology , microbiology and biotechnology , polymer , organic chemistry
Magnetic resonance (MR) imaging and relaxation time measurements of bioresorbable implants made of polylactic acid (PLA), as well as the surrounding tissues, were carried out over a period of 6 months to monitor the implant state and the body's responses, and to determine how these processes are reflected in MR data. Twelve rabbits each received two subcutaneous PLA implants (45 × 10 × 2 mm). Changes in tissue relaxation rates demonstrated inflammation and tissue healing time courses but were not simply linear functions of the tissue water content and so provide new insight into MR characterization of inflammatory processes. Magn Reson Med 42:210–214, 1999. © 1999 Wiley‐Liss, Inc.