Premium
Multicomponent T 2 relaxation of in vivo skeletal muscle
Author(s) -
Saab George,
Thompson R. Terry,
Marsh Greg D.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199907)42:1<150::aid-mrm20>3.0.co;2-5
Subject(s) - in vivo , nuclear magnetic resonance , t2 relaxation , relaxation (psychology) , voxel , chemistry , extracellular , ex vivo , biomedical engineering , anatomy , magnetic resonance imaging , physics , medicine , biology , radiology , neuroscience , biochemistry , microbiology and biotechnology
In vivo spin‐spin (T 2 ) relaxation measurements were acquired from the flexor digitorum profundus (FDP) of 13 subjects. A standard imaging T 2 measurement technique [number of points ( N ) = 6, TE = 18 msec, signal‐to‐noise ratio (SNR) ≅ 300] yielded a single T 2 value of 31 msec. A novel technique, projection presaturation combined with a CPMG sequence, was used to acquire data ( N = 1000, TE = 1.2 msec, SNR 3500) from a cylindrical voxel (2 cm diameter, 5 cm length) within the FDP. All 13 subjects had at least four T 2 components, at <5, 21 ± 4, 39 ± 6, and 114 ± 31 msec, with fractional areas of 11 ± 2, 28 ± 15, 46 ± 12, and 11 ± 5% respectively. The shortest and longest components have been observed in ex vivo muscle studies, probably corresponding to water associated with macromolecules and extracellular water, respectively. The middle T 2 components are suggestive of an organization of in vivo intracellular water. Magn Reson Med 42:150–157, 1999. © 1999 Wiley‐Liss, Inc.