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QUIPSS II with thin‐slice TI 1 periodic saturation: A method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling
Author(s) -
Luh WenMing,
Wong Eric C.,
Bandettini Peter A.,
Hyde James S.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199906)41:6<1246::aid-mrm22>3.0.co;2-n
Subject(s) - multislice , saturation (graph theory) , arterial spin labeling , nuclear magnetic resonance , perfusion , materials science , perfusion scanning , nuclear medicine , subtraction , biomedical engineering , physics , radiology , medicine , mathematics , combinatorics , arithmetic
Quantitative imaging of perfusion using a single subtraction, second version (QUIPSS II) is a pulsed arterial spin labeling (ASL) technique for improving the quantitation of perfusion imaging by minimizing two major systematic errors: the variable transit delay from the distal edge of the tagged region to the imaging slices, and the contamination by intravascular signal from tagged blood that flows through the imaging slices. However, residual errors remain due to incomplete saturation of spins over the slab‐shaped tagged region by the QUIPSS II saturation pulse, and spatial mismatch of the distal edge of the saturation and inversion slice profiles. By replacing the original QUIPSS II saturation pulse with a train of thin‐slice periodic saturation pulses applied at the distal end of the tagged region, the accuracy of perfusion quantitation is improved. Results of single and multislice studies are reported. Magn Reson Med 41:1246–1254, 1999. © 1999 Wiley‐Liss, Inc.