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31 P MRS studies of exercising human muscle at high temporal resolution
Author(s) -
Boska M.D.,
Nelson J.A.,
Sripathi N.,
Pipinos I.I.,
Shepard A.D.,
Welch K.M.A.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199906)41:6<1145::aid-mrm10>3.0.co;2-w
Subject(s) - phosphocreatine , peripheral , medicine , metabolite , magnetic resonance imaging , cardiology , nuclear magnetic resonance , energy metabolism , radiology , physics
Methods for measuring mitochondrial activity from 31 P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non‐exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Q max calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery. Magn Reson Med 41:1145–1151, 1999. © 1999 Wiley‐Liss, Inc.