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Analysis of functional magnetic resonance imaging data using self‐organizing mapping with spatial connectivity
Author(s) -
Ngan ShingChung,
Hu Xiaoping
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199905)41:5<939::aid-mrm13>3.0.co;2-q
Subject(s) - functional magnetic resonance imaging , magnetic resonance imaging , nuclear magnetic resonance , computer science , physics , medicine , radiology
Commonly used methods in analyzing functional magnetic resonance imaging (fMRI) data, such as the Student's t‐test and cross‐correlation analysis, are model‐based approaches. Although these methods are easy to implement and are effective in analyzing data obtained with simple paradigms, they are not applicable in situations in which patterns of neuronal response are complicated and when fMRI response is unknown. In this work, Kohonen's self‐organizing mapping (SOM), which is a model‐free approach, is adapted for analyzing fMRI data. Because spatial connectivity is an important function in the identification of activation sites in functional brain imaging, it is incorporated into the SOM algorithm. Receiver operating characteristic analysis on simulated data shows that the new algorithm achieves measurable improvement over the standard algorithm. The applicability of the new algorithm is demonstrated on experimental data. Magn Reson Med 41:939–946, 1999. © 1999 Wiley‐Liss, Inc.