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Longitudinal relaxation times of 129 Xe in rat tissue homogenates at 9.4 T
Author(s) -
Wilson Gregory J.,
Santyr Giles E.,
Anderson Mark E.,
DeLuca Paul M.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199905)41:5<933::aid-mrm12>3.0.co;2-z
Subject(s) - nuclear magnetic resonance , chemistry , relaxation (psychology) , biophysics , biology , physics , medicine
Longitudinal relaxation times of 129 Xe were measured in homogenates of rat brain, kidney, liver, and lung at varying oxygenation levels as a means to assess the feasibility of magnetic resonance (MR) imaging of tissue using laser‐polarized (LP) 129 Xe as the signal source. The measured relaxation times ranged from 4.4 ± 0.4 sec in deoxygenated lung homogenate to 22 ± 2 sec in deoxygenated brain homogenate. When the LP gas is introduced to the subject via inhalation, these relaxation times are long enough to allow accumulation and subsequent MR imaging of LP 129 Xe in tissues. Imaging of dissolved LP 129 Xe will yield an intrinsic signal‐to‐noise ratio (SNR) that is approximately 3% of the proton intrinsic SNR. This relatively low intrinsic SNR is expected to be adequate for some tracer applications. T 1 of 129 Xe was found to depend on the oxygenation level of the tissue, and the effect of oxygenation is likely dependent on the amount of hemoglobin in the tissue homogenate. Magn Reson Med 41:933–938, 1999. © 1999 Wiley‐Liss, Inc.