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Chemical shift artifact‐free microscopy: Spectroscopic microimaging of the human skin
Author(s) -
Weis Jan,
Ericsson Anders,
Hemmingsson Anders
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199905)41:5<904::aid-mrm8>3.0.co;2-4
Subject(s) - artifact (error) , microscopy , human skin , nuclear magnetic resonance , materials science , chemistry , optics , computer science , physics , computer vision , biology , genetics
A spectroscopic imaging technique with high spatial resolution was used for the study of human skin in vivo. The measurements were performed using a whole‐body magnetic resonance system (1.5 T) with standard gradients and a standard 8‐cm diameter circular surface coil. A decisive gain in signal‐to‐noise ratio was achieved by reducing the receiver bandwidth of the imaging system to values less than ±5 kHz. The chemical shift misregistration was eliminated by post‐detection data processing. The method was tested on different kinds of skin, on the foot sole and head. Water, fat, and chemical shift artifact‐free images were obtained with resolution 0.107 × 0.143 mm in plane and slice thickness 1 mm. A major advantage of the spectroscopic imaging procedure is that the pulse sequence can be optimized for the maximum signal‐to‐noise ratio. There is no need for special modification of the sequence to circumvent the chemical shift artifacts (water, fat suppression, etc.). Magn Reson Med 41:904–908, 1999. © 1999 Wiley‐Liss, Inc.