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Functional MRI of the human brain with GRASE‐based BOLD contrast
Author(s) -
Jovicich Jorge,
Norris David G.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199905)41:5<871::aid-mrm3>3.0.co;2-o
Subject(s) - blood oxygenation , functional magnetic resonance imaging , magnetic resonance imaging , susceptibility weighted imaging , nuclear magnetic resonance , blood oxygen level dependent , gradient echo , physics , neuroscience , psychology , medicine , radiology
The application of T 2 *‐weighted gradient and spin‐echo (GRASE) imaging was investigated as a method for blood oxygenation level‐dependent (BOLD)‐based functional magnetic resonance imaging (fMRI). The displaced‐echo method was implemented to produce single‐shot T 2 *‐weighted GRASE images. This technique removes the requirement that the Carr‐Purcell Meiboom‐Gill (CPMG) condition be fulfilled. T 2 *‐weighted GRASE images that are free from interference artifacts can thus be obtained, hence allowing the possibility of using single‐shot GRASE for BOLD‐based functional imaging. The method was demonstrated at 3 T and gave robust and reproducible activation‐induced signal changes. Magn Reson Med 41:871–876, 1999. © 1999 Wiley‐Liss, Inc.