Premium
Evidence for bi‐exponential transverse relaxation of lactate in excised rat muscle
Author(s) -
Jouvensal Laurence,
Carlier Pierre G.,
Bloch Gilles
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199903)41:3<624::aid-mrm27>3.0.co;2-w
Subject(s) - exponential function , transverse plane , relaxation (psychology) , nuclear magnetic resonance , chemistry , physics , anatomy , mathematics , medicine , biology , mathematical analysis
To elucidate the low proton nuclear magnetic resonance (NMR) visibility of muscle lactate previously demonstrated in excised rat muscle, lactate transverse relaxation was investigated in the same model using double quantum editing sequences with effective echo times ranging from 55 to 475 msec. On this time scale, muscle lactate clearly exhibits a bi‐exponential transverse relaxation with a short T 2 of 33 ± 5 msec (mean ± SE, n = 3) and a long T 2 of 230 ± 10 msec. The relative populations (84 ± 4% vs. 16 ± 4%, respectively) of these two lactate pools are compatible with compartmentation between intra‐ and extracellular muscle lactate. Magn Reson Med 41:624–626, 1999. © 1999 Wiley‐Liss, Inc.