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Perfluorocarbon emulsions as intravenous delivery media for hyperpolarized xenon
Author(s) -
Wolber Jan,
Rowland Ian J.,
Leach Martin O.,
Bifone Angelo
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199903)41:3<442::aid-mrm3>3.0.co;2-7
Subject(s) - xenon , chemistry , isotopes of xenon , emulsion , nmr spectra database , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , spectral line , bromide , stereochemistry , organic chemistry , physics , astronomy
The use of perfluorooctyl bromide (PFOB) emulsions as delivery media for hyperpolarized xenon has been investigated. Emulsion droplet size was controlled by varying the content of egg yolk phospholipid (EYP), which served as an emulsifier. Hyperpolarized 129 Xe nuclear magnetic resonance (NMR) spectra of the dissolved gas were obtained. The NMR spectra were found to be correlated strongly with the emulsion droplet size distribution. The NMR line width is determined by xenon exchange between the PFOB droplets and the aqueous environment. Our findings show that, in a 1.5‐Tesla field, relatively narrow 129 Xe NMR spectra are obtained for droplet sizes larger than 5 μm. Preliminary results on animal models show that PFOB emulsions have potential as hyperpolarized 129 Xe carriers for in vivo magnetic resonance applications. Magn Reson Med 41:442–449, 1999. © 1999 Wiley‐Liss, Inc.