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In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance
Author(s) -
Dousset Vincent,
Delalande Christophe,
Ballarino Lucrecia,
Quesson Bruno,
Seilhan Danielle,
Coussemacq Monique,
Thiaudiére Eric,
Brochet Bruno,
Canioni Paul,
Caillé JeanMarie
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199902)41:2<329::aid-mrm17>3.0.co;2-z
Subject(s) - central nervous system , magnetic resonance imaging , in vivo , macrophage , mononuclear phagocyte system , microglia , experimental autoimmune encephalomyelitis , pathology , multiple sclerosis , encephalomyelitis , medicine , chemistry , nuclear magnetic resonance , biology , neuroscience , in vitro , inflammation , immunology , biochemistry , radiology , microbiology and biotechnology , physics
Cell‐specific imaging has been proposed to increase the potential of magnetic resonance imaging (MRI) for tissue analysis. The hypothezis of the present work was that following intravenous injection of ultra‐small particle iron oxide, a contrast agent that accumulates in mononuclear phagocyte cells, macrophages with iron burden would be detectable by MRI within the central nervous system at sites of inflammatory cellular activity. In experimental autoimmune encephalomyelitis in Lewis rats (in which intense macrophage activity results from both hematogenous macrophages and activated microglia), lesions have been seen by MRI as low signal intensities related to magnetic susceptibility effects induced by iron particles. Electron microscopy has revealed the presence of such particles within the cytoplasm of cells that had the morphological aspect of macrophages. Macrophage activity imaging might increase MRI capability with regard to the in vivo pathophysiological aspects of central nervous system (CNS) diseases and might help in therapeutic trials in the numerous CNS diseases in which macrophages are involved. Magn Reson Med 41:329–333, 1999. © 1999 Wiley‐Liss, Inc.

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