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Investigation of the early response to rat forepaw stimulation
Author(s) -
Marota John J.A.,
Ayata C.,
Moskowitz Michael A.,
Weisskoff Robert M.,
Rosen Bruce R.,
Mandeville Joseph B.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199902)41:2<247::aid-mrm6>3.0.co;2-u
Subject(s) - stimulation , cerebral blood flow , somatosensory system , blood volume , laser doppler velocimetry , hemodynamics , cerebral blood volume , blood flow , medicine , nuclear medicine , neuroscience , anesthesia , cardiology , psychology
The role of relative cerebral blood volume (rCBV) in the early response of blood oxygenation level‐dependent (BOLD) signal following sensory stimulation was assessed. Magnetic resonance imaging (MRI) measurements of rCBV and BOLD signal as a function of time (t) were compared with relative cerebral blood flow (rCBF) obtained by laser doppler flowmetry during a repeated epoch of rat forepaw stimulation in which 6 sec of electrical stimulation followed 54 sec of rest. rCBF(t) exceeded rCBV(t) in somatosensory cortex at all time points and reached a maximal increase (60%) during a 6 sec stimulation that was much higher than maximal rCBV (10%). An initial dip was not observed in BOLD signal, which showed a delay with respect to rCBF that was roughly consistent with the cerebral blood transit time. Magn Reson Med 41:247–252, 1999. © 1999 Wiley‐Liss, Inc.