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Application of double voxel functional spectroscopy to event‐related cognitive experiments
Author(s) -
Dymond Rosemary,
Norris David G.,
Pollmann Stefan,
Zysset Stefan
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199902)41:2<217::aid-mrm1>3.0.co;2-b
Subject(s) - functional magnetic resonance imaging , voxel , visual cortex , haemodynamic response , computer science , nuclear magnetic resonance , artificial intelligence , neuroscience , functional imaging , pattern recognition (psychology) , computer vision , psychology , physics , medicine , heart rate , blood pressure , radiology
The hemodynamic response to functional activation can be regarded as the convolution of the neuronal response with an unknown kernel. As such, it introduces an intrinsic blurring that limits the attainable temporal resolution of functional magnetic resonance (fMR) techniques. This study demonstrates that by measurement of displacements in activation onsets between different types of trial, it is nevertheless possible to obtain a subsecond temporal accuracy in fMR. A single trial stimulation paradigm was adopted: a simple search task embedded in a longer period of visual flicker stimulation that produced reliable activations in the primary visual cortex and supplementary motor area. Data were acquired from both of these regions using double voxel functional spectroscopy.Magn Reson Med 41:217–223, 1999. © 1999 Wiley‐Liss, Inc.