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Sodium NMR evaluation of articular cartilage degradation
Author(s) -
Insko Erik K.,
Kaufman Jonathan H.,
Leigh John S.,
Reddy Ravinder
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199901)41:1<30::aid-mrm6>3.0.co;2-u
Subject(s) - articular cartilage , degradation (telecommunications) , cartilage , nuclear magnetic resonance , chemistry , medicine , computer science , osteoarthritis , physics , pathology , anatomy , alternative medicine , telecommunications
One of the first effects of degenerative osteoarthritis is the loss of proteoglycans from the matrix of articular cartilage. Using a model of osteoarthritic change where the cartilage has been enzymatically degraded with trypsin, the sodium NMR characteristics of the cartilage were determined as a function of changes in the proteoglycan content. The results demonstrate that the single quantum sodium signal decreases as the proteoglycan content of the cartilage matrix decreases. In addition, the relaxation characteristics of the sodium change such that the T 1 is longer, the T 2s is longer, and the T 2f is shorter. Short echo‐time, T 1 ‐weighted sodium images are presented which demonstrate that this information may be utilized to detect the loss of proteoglycans from articular cartilage. Magn Reson Med 41:30‐34, 1999. © 1999 Wiley‐Liss, Inc.