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Localized proton MRS of the human hippocampus: Metabolite concentrations and relaxation times
Author(s) -
Choi Choong Gon,
Frahm Jens
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199901)41:1<204::aid-mrm29>3.0.co;2-7
Subject(s) - creatine , metabolite , nuclear magnetic resonance , choline , white matter , neocortex , chemistry , human brain , hippocampus , relaxation (psychology) , phosphocreatine , lateralization of brain function , endocrinology , biology , magnetic resonance imaging , neuroscience , biochemistry , medicine , physics , radiology , energy metabolism
Absolute concentrations and proton relaxation times of major metabolites in the human hippocampus were determined with use of fully relaxed, short‐echo time STEAM localization sequences at 2.0 T (20 normal adults). Mean metabolite concentrations were 7.6 ± 0.9 mM for total N ‐acetylaspartate (tNAA), 6.9 ± 0.8 mM for total creatine (tCr), 2.1 ± 0.3 mM for choline‐containing compounds (Cho), and 6.2 ± 0.9 mM for myo ‐inositol (Ins). The observation of relatively low tNAA and high Cho and Ins levels compared with cortical gray and white matter corresponds to a lower neuronal density and higher glial density than in the neocortex, in agreement with histologic findings. The data do not support a lateralization of metabolites. T1 and T2 relaxation times were in the range of 1400–1730 and 140–330 msec, respectively, similar to those in other brain regions. Magn Reson Med 41:204‐207, 1999.© 1999 Wiley‐Liss, Inc.