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Inverse correlation between choline magnetic resonance spectroscopy signal intensity and the apparent diffusion coefficient in human glioma
Author(s) -
Gupta Rakesh K.,
Sinha Usha,
Cloughesy Timothy F.,
Alger Jeffry R.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199901)41:1<2::aid-mrm2>3.0.co;2-y
Subject(s) - glioma , nuclear magnetic resonance , magnetic resonance imaging , effective diffusion coefficient , diffusion mri , intensity (physics) , human brain , choline , diffusion , chemistry , proton magnetic resonance , nuclear medicine , medicine , physics , radiology , optics , cancer research , biochemistry , psychiatry , thermodynamics
Magnetic resonance spectroscopy and diffusion magnetic resonance imaging (MRI) characteristics of human intracranial glioma were studied. Present knowledge suggests a hypothetical inverse relationship between the characteristic choline signal intensity elevation and the apparent diffusion coefficient (ADC) in glioma. Twenty cases of glioma were examined with diffusion‐weighted echoplanar imaging and proton magnetic resonance spectroscopic imaging ( 1 H‐MRSI). A statistically significant inverse correlation between the choline signal intensity and the ADC was found ( P = 0.0004) in radiologically defined tumor‐containing regions. This study is the first in which diffusion MRI and 1 H‐MRSI were used to evaluate human intracranial glioma jointly. It provides insight into how to interpret choline signal intensity elevation in terms of tumor cellularity and proliferative potential when ADC images are also available. Magn Reson Med 41:2‐7, 1999. © 1999 Wiley‐Liss, Inc.