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A method for fast multislice T1 measurement: Feasibility studies on phantoms, young children, and children with canavan's disease
Author(s) -
Haselgrove John,
Moore James,
Wang Zhiyue,
Traipe Elfrides,
Bilaniuk Larissa
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(200004)11:4<360::aid-jmri3>3.0.co;2-g
Subject(s) - multislice , computer science , range (aeronautics) , signal (programming language) , protocol (science) , algorithm , nuclear medicine , medicine , materials science , alternative medicine , pathology , composite material , programming language
We have developed a multislice protocol for quantitative T1 measurements in which the processing time and the acquisition time are under 2 minutes each for a complete brain study of 15 slices. An echoplanar, inversion‐recovery image sequence is designed to collect data suitable for analysis using a linear regression algorithm. The precision is approximately twice the noise to signal ratio of the images. The accuracy of the protocol is better than 1% for T1 in the range 0–2 seconds and deviates slightly for longer T1 values. The protocol is insensitive to B1 field values. If needed, the data can be postprocessed using a slow, nonlinear algorithm to give an accuracy of less than 1% and a precision of approximately the noise to signal ratio throughout a range of T1 values from 0 to 4 seconds. J. Magn. Reson. Imaging 2000;11:360–367. © 2000 Wiley‐Liss, Inc.