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In vivo hahn spin‐echo decay (Hahn‐T 2 ) observation of regional changes in the time course of oleic acid lung injury
Author(s) -
Shioya Sumie,
Christman Rebecca,
Ailion David C.,
Cutillo Antonio G.,
Goodrich K. Craig,
Morris Alan H.
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(200002)11:2<215::aid-jmri21>3.0.co;2-e
Subject(s) - oleic acid , edema , in vivo , lung , nuclear magnetic resonance , nuclear medicine , spin echo , chemistry , medicine , physics , radiology , biology , magnetic resonance imaging , biochemistry , microbiology and biotechnology
We studied the time course of changes in the Hahn spin‐echo decay (Hahn‐T 2 ) in lungs of spontaneously breathing living rats at 1 hour, 3 hours, and 7 days following oleic acid injection. Motion artifacts were minimized by using the motion‐insensitive interleaved rapid line scan (ILS) imaging technique. Prior to injury, the lungs exhibited two resolvable exponential Hahn‐T 2 components. One and 3 hours after injury the decay showed a regionally nonuniform behavior, which was fit with one, two, or three exponential components. The short and medium components increased at 1 and 3 hours after injection. The third, much longer, component is probably due to intraalveolar pulmonary edema. After 7 days the Hahn decay was similar to that observed before injury, probably reflecting resolution of the edema. Our data suggest that Hahn‐T 2 measurements can be used to characterize the time course and regional distribution of lung injury in living animals. J. Magn. Reson. Imaging 2000;11:215–222. © 2000 Wiley‐Liss, Inc.