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Sodium and proton MR properties of cartilage during compression
Author(s) -
Regatte Ravinder Reddy,
Kaufman Jonathan H.,
Noyszewski Elizabeth A.,
Reddy Ravinder
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199912)10:6<961::aid-jmri8>3.0.co;2-a
Subject(s) - cartilage , relaxation (psychology) , sodium , uncompressed video , materials science , proton , compression (physics) , magnetic resonance imaging , nuclear magnetic resonance , biomedical engineering , chemistry , anatomy , physics , radiology , composite material , medicine , quantum mechanics , video tracking , metallurgy , naturalness
Proton and sodium MR relaxation times of bovine articular cartilage specimens were measured as a function of proteoglycan (PG) depletion and as a function of mechanical compression. Proton and sodium relaxation times of normal cartilage were compared with relaxation times of PG‐depleted cartilage to evaluate the significance of PG depletion‐induced changes in MR relaxation parameters. These comparisons were conducted for both uncompressed and mechanically compressed states. The mechanical compressions were performed with an MR‐compatible pressure cell and evaluated dynamically via interleaved one‐dimensional proton and sodium MR projection imaging. The comparisons indicate that sodium relaxation parameters are sensitive to PG depletion when cartilage is in a mechanically compressed state or an uncompressed state. In contrast, proton relaxation parameters do not change significantly with PG depletion when cartilage is in an uncompressed state. However, during mechanical compression, proton T2 becomes sensitive to PG depletion. These results support the potential of sodium magnetic resonance imaging (MRI) as a possible modality for obtaining imaging contrast related to PG depletion. The results also indicate the potential of proton MRI to provide such contrast if the image acquisition is conducted in conjunction with a mechanical compression via physical exercise.J. Magn. Reson Imaging 10:961–967, 1999. © 1999 Wiley‐Liss, Inc.