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A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images
Author(s) -
Barbier Emmanuel L.,
den Boer Jacques A.,
Peters Anton R.,
Rozeboom Alfred R.,
Sau Jacques,
Bonmartin Alain
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199909)10:3<242::aid-jmri4>3.0.co;2-h
Subject(s) - blood volume , perfusion , interstitial space , perfusion scanning , dynamic contrast enhanced mri , nuclear medicine , epirubicin , medicine , magnetic resonance imaging , radiology , pathology , surgery , cardiology , chemotherapy , cyclophosphamide
An optimized dynamic gradient echo sequence with two echoes is used to obtain data that can be analyzed with indicator dilution theory as well as with pharmacokinetic theory. Taking advantage of the simultaneity of T * 2and T 1 information, both theories can be employed and merged to interpret consistently the observed effects of the redistribution of a contrast agent (gadopentetate dimeglumine) into the tissue from first pass onward. The regional cerebral blood volume (rCBV) and the exchange rate of the contrast agent between the vascular and the interstitial space through the blood‐brain barrier are analyzed for each pixel in a two‐step algorithm. Two values for rCBV are obtained with different weighting for the microvascular fraction of the blood volume. Because the analysis, called PELEAKAN, is capable of separating effects related to perfusion (through intravascular blood volume) and to leakage in places where the blood‐brain barrier is damaged, it is an appropriate tool for evaluating these parameters in brain tumors, and we show clinical examples of this analysis in brain tumor patients. J. Magn. Reson. Imaging 1999;10:242–253. © 1999 Wiley‐Liss, Inc.