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MR perfusion imaging in human brain using the UNFAIR technique
Author(s) -
Tanabe Jody L.,
Yongbi Martin,
Branch Craig,
Hrabe Jan,
Johnson Glyn,
Helpern Joseph A.
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199906)9:6<761::aid-jmri2>3.0.co;2-c
Subject(s) - arterial spin labeling , cerebral blood flow , spins , magnetic resonance imaging , nuclear magnetic resonance , perfusion , computer science , blood flow , pulse sequence , fluid attenuated inversion recovery , white matter , artificial intelligence , medicine , physics , radiology , cardiology
Pulsed arterial spin labeling magnetic resonance techniques have been developed recently to estimate cerebral blood flow (CBF). Flow‐sensitive alternating inversion recovery (FAIR) is one such technique that has been implemented successfully in humans. Un‐inverted FAIR (UNFAIR) is an alternative technique in which the flow‐sensitive image is acquired following inversion of all spins outside the slice of interest, and the control image is acquired without any spin labeling. This approach is potentially more efficient than FAIR since the UNFAIR control image is entirely flow independent and need only be acquired once. Here, we describe implementation of the sequence on a clinical 1.5 T magnetic resonance system. Both FAIR and UNFAIR perfusion‐weighted images were obtained from six normal volunteers. Wash‐in/wash‐out curves measured in cortical gray and white matter were practically identical for the two techniques, as predicted by our model. J. Magn. Reson. Imaging 1999;9:761–767. © 1999 Wiley‐Liss, Inc.