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A novel approach to observing articular cartilage deformation in vitro via magnetic resonance imaging
Author(s) -
Kaufman Jonathan H.,
Regatte Ravinder Reddy,
Bolinger Lizann,
Kneeland J. Bruce,
Reddy Ravinder,
Leigh John S.
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199905)9:5<653::aid-jmri6>3.0.co;2-4
Subject(s) - articular cartilage , magnetic resonance imaging , nuclear magnetic resonance , cartilage , medicine , deformation (meteorology) , materials science , biomedical engineering , osteoarthritis , radiology , anatomy , pathology , physics , composite material , alternative medicine
The design of a pressure cell that compresses a cartilage specimen in one dimension within an imaging magnet is presented. One‐dimensional projection images in a direction perpendicular to the articular surface of the cartilage specimen were used to generate a uniaxial confined deformation creep curve for normal and trypsin‐degraded cartilage specimens during a continuous 0.690 MPa (100 psi) pressure application. The resulting curves are shown to fit a two time constant viscoelastic model well and also indicate that the elastic modulus of cartilage decreases and the deformation rate increases upon trypsin proteolysis. Furthermore, cartilage permeability is shown as a function of cartilage strain for both the normal and trypsin‐degraded case. Several two‐dimensional slice‐selective images were collected both before and after 80 minutes of continuous compression. These images were used to evaluate the relative changes in the spin‐lattice, T1, and spin‐spin, T2, relaxation time constant maps for both normal and degraded cartilage specimens in response to compression. The results of this study demonstrate the utility of a novel, non‐magnetic, cartilage compression device and also support the validity of a simple two‐component rheological model of articular cartilage. J. Magn. Reson. Imaging 1999;9:653–662. © 1999 Wiley‐Liss, Inc.