Premium
Assessment of hepatic perfusion in pigs by pharmacokinetic analysis of dynamic MR images
Author(s) -
Scharf Johann,
Zapletal Christina,
Hess Thomas,
Hoffmann Ulf,
Mehrabi Arianeb,
Mihm David,
Hoffmann Volker,
Brix Gunnar,
Kraus Thomas,
Richter Götz Martin,
Klar Ernst
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199904)9:4<568::aid-jmri10>3.0.co;2-1
Subject(s) - perfusion , medicine , magnetic resonance imaging , nuclear medicine , occlusion , first pass , ultrasound , portal vein , pharmacokinetics , perfusion scanning , radiology , mathematics , arithmetic
The purpose of this study was to evaluate a new method based on magnetic resonance imaging for the characterization of hepatic perfusion. In nine pigs dynamic MRI was performed before and after partial occlusion of the portal vein. The pharmacokinetic analysis of the contrast enhancement resulted in a set of parameters (amplitude, A ; perfusion rate, k p ; elimination rate, k el ; lag time, t lag ) of which k p was expected to correlate with hepatic perfusion. Reference measurements were done with ultrasound flowmeters and with a thermal diffusion probe (TDP). MR perfusion rate k p significantly dropped under partial portal vein occlusion from an average of 11.3 to 4.9 min −1 ( P < 0.001), while the difference in amplitude A was not significant. The correlation between k p and the TDP measurement was r = 0.89 ( P < 0.001). Pharmacokinetic analysis of MRI contrast enhancement provides a non‐invasive assessment of hepatic perfusion.J. Magn. Reson. Imaging 1999;9:568–572. © 1999 Wiley‐Liss, Inc.