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Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple‐quantum‐filtered signals
Author(s) -
Kmiecik Joseph A.,
Gregory Carl D.,
Liang ZhiPei,
Lauterbur Paul C.,
Dawson M. Joan
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199904)9:4<539::aid-jmri5>3.0.co;2-a
Subject(s) - gerbil , magnetic resonance imaging , medicine , stroke (engine) , ischemic stroke , pathology , ligation , ischemia , nuclear magnetic resonance , nuclear medicine , neuroscience , cardiology , biology , radiology , physics , thermodynamics
Quantitative magnetic resonance imaging of lactate using a zero‐quantum/double‐quantum filter and generalized spectral localization by imaging (GSLIM) was applied to a model of unilateral stroke in gerbil brain. GSLIM lactate images at 4T clearly reveal elevated concentrations of lactate in the ischemic compared with the normal hemisphere 100–175 minutes after unilateral carotid ligation. These results indicate that the technique is capable of studies of brain infarcts, and that application to human ischemic pathology in brain and other tissues may be possible.J. Magn. Reson. Imaging 1999;9:539–543. © 1999 Wiley‐Liss, Inc.