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The contributory role of interstitial water in Gd‐DTPA‐enhanced MRI in myocardial infarction
Author(s) -
Inoue Shinichi,
Murakami Yo,
Ochiai Koichi,
Kitamura Jun,
Ishibashi Yutaka,
Kawamitsu Hideaki,
Sugimura Kazuro,
Shimada Toshio
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199902)9:2<215::aid-jmri10>3.0.co;2-#
Subject(s) - myocardial infarction , medicine , cardiology , gadolinium , magnetic resonance imaging , radiology , materials science , metallurgy
We studied the mechanism underlying regional enhancement of myocardial infarction using T1‐weighted MRI with gadolinium (Gd)‐DTPA. Anterior myocardial infarction (MI) was produced by left anterior descending coronary artery ligation in three groups of rats as follows: 60 minutes occlusion (occlusion group, N = 6), 60 minutes occlusion plus 120 minutes reperfusion (reperfusion group, N = 8), and sham‐operated (control, N = 6). In Gd‐DTPA‐enhanced MRI, MI was demarcated as a hypoenhanced region in the occlusion group and as a homogeneous hyperenhanced region in the reperfusion group. Both Gd‐DTPA tissue concentration and tissue water content in the anterior wall were highest in the reperfusion group ( P < 0.05), a finding suggestive of microscopically observed interstitial edema. The data suggest that regional accumulation of Gd‐DTPA in the reperfused group can be explained by increased interstitial water content, contributing to the delayed washout of the water‐soluble contrast medium. J. Magn. Reson. Imaging 1999;9:215–219. © 1999 Wiley‐Liss, Inc.