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Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function
Author(s) -
Vallée JeanPaul,
Lazeyras François,
Kasuboski Larry,
Chatelain Pascal,
Howarth Nigel,
Righetti Alberto,
Didier Dominique
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199902)9:2<197::aid-jmri7>3.0.co;2-x
Subject(s) - gadolinium , perfusion , magnetic resonance imaging , bolus (digestion) , pulse sequence , in vivo , nuclear medicine , nuclear magnetic resonance , magnetization transfer , intravenous bolus , blood volume , calibration , medicine , biomedical engineering , chemistry , radiology , mathematics , physics , microbiology and biotechnology , organic chemistry , biology , statistics
The present study reports on a new calibration of the magnetic resonance imaging (MRI) signal intensity of a fast gradient‐echo sequence used for in vivo myocardial perfusion quantification in patients. The signal from a FAST sequence preceded by a arrhythmia‐insensitive magnetization preparation was calibrated in vitro using tubes filled with various gadolinium (Gd) solutions. Single short‐axis views of the heart were obtained in patients ( n = 10) with normal cardiac function. Myocardial and blood signal intensity were converted to concentration of Gd according to the in vitro calibration curve and fitted by a one‐compartment model. K 1 [first‐order transfer constant from the blood to the myocardium for the gadolinium‐diethylene‐triamine‐pentaacetic acid (Gd‐DTPA)] and V d (distribution volume of Gd‐DTPA in myocardium) obtained from the fit of the MRI‐derived perfusion curves were 0.72 ± 0.22 (mL/min/g) and 15.3 ± 5.22%. These results were in agreement with previous observations on animals and demonstrated that a reliable measurement of myocardial perfusion can be obtained by MRI in patients with an in vitro calibration procedure.J. Magn. Reson. Imaging 1999;9:197–203. © 1999 Wiley‐Liss, Inc.