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Assessment of myocardial function and perfusion in a canine model of non‐occlusive coronary artery stenosis using fast magnetic resonance imaging
Author(s) -
Schwitter Juerg,
Saeed Maythem,
Wendland Michael F.,
Sakuma Hajime,
Bremerich Jens,
Canet Emmanuelle,
Higgins Charles B.
Publication year - 1999
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/(sici)1522-2586(199901)9:1<101::aid-jmri14>3.0.co;2-9
Subject(s) - medicine , perfusion , dipyridamole , stenosis , ventricle , magnetic resonance imaging , perfusion scanning , cardiology , blood flow , circumflex , artery , radiology , nuclear medicine
Abstract Magnetic resonance (MR) functional and perfusion imaging were employed in a canine model of coronary artery stenosis ( n = 6) for the quantification of functional and perfusion deficits before and after dipyridamole administration. Left anterior descending and circumflex (LCX) coronary blood flow were measured continuously after placing Doppler flowmeters. Inversion recovery gradient echo images during the transit of MR contrast medium gadolinium‐benzyloxypropionictetraacetate dimeglumine (Gd‐BOPTA/Dimeg) and fast breath‐hold cine MR images were acquired at baseline, during LCX stenosis in basal state, and during LCX stenosis with vasodilation (dipyridamole 0.5 mg/kg). The extent of the functional defect and perfusion defect was expressed as percent of left ventricle (LV) circumference. During stenosis (LCX flow: 62.6 ± 5.6% of baseline) the extent of the functional defect was slightly larger than the perfusion defect (11.0 ± 1.8% versus 6.3 ± 1.7% of LV circumference, respectively; P < 0.01). During vasodilation the extent of the functional defect was considerably smaller than the perfusion defect (25.3 ± 2.5% versus 35.3 ± 3.5%; P < 0.01). Thus, the sizes of ischemic regions displayed by MR perfusion defect and functional defect differ from each other. J. Magn. Reson. Imaging 1999; 9:101–110. J. Magn. Reson. Imaging 1999;9:101–110 © 1999 Wiley‐Liss, Inc.