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N ‐(1‐Cyanocyclohexyl)‐ C ‐phenylnitrones and Glyoxaldinitrones
Author(s) -
Camehn Rainer,
Rehse Klaus
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(20005)333:5<130::aid-ardp130>3.0.co;2-d
Subject(s) - antithrombotic , nitric oxide , chemistry , thrombus , stereochemistry , in vitro , oxygen , medicinal chemistry , biochemistry , medicine , organic chemistry
Six N ‐(1‐cyanocyclohexyl)‐ C ‐phenylnitrones 4a — f ( 4b — f for the first time) and 22 glyoxaldinitrones 7a — v were prepared and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Both classes of compounds exhibit considerable antithrombotic activities. Maximum inhibition of thrombus formation in arterioles (21%) was observed in N,N′ ‐bis‐2‐phenylethylglyoxaldinitrone ( 7o ) and N,N′ ‐bis‐4‐nitrobenzylglyoxaldinitrone ( 7u ). The compounds form only small amounts of nitric oxide in vitro by the addition of a Fe 3+ ‐porphyrine complex and an oxygen donor