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Synthesis of New N ‐(4‐Pyridyl)‐1‐aminopyrazoles and Their Muscarinic and Adrenergic Properties
Author(s) -
RodríguezFranco María Isabel,
Dorronsoro Isabel,
Martínez Ana,
Pérez Concepción,
Badía Albert,
Ban˜os Josep E.
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(20005)333:5<118::aid-ardp118>3.0.co;2-q
Subject(s) - muscarinic acetylcholine receptor , chemistry , acetylcholinesterase , adrenergic , neurotransmitter receptor , parasympatholytic , neurotransmitter , inhibitory postsynaptic potential , adrenergic receptor , muscarinic antagonist , pyrazole , muscarinic acetylcholine receptor m3 , receptor , stereochemistry , pharmacology , biochemistry , endocrinology , enzyme , biology
The synthesis of new N ‐(4‐pyridyl)‐1‐aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5‐dimethyl‐1 H ‐ pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests