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Analysis of Salbutamol and Related Impurities by Derivative Spectrometry
Author(s) -
AboulEnein Hassan Y.,
Surmeian Mariana
Publication year - 2000
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(20004)333:4<75::aid-ardp75>3.0.co;2-f
Subject(s) - salbutamol , derivative (finance) , chemistry , impurity , ketone , mass spectrometry , chromatography , aldehyde , sodium hydroxide , nuclear chemistry , organic chemistry , catalysis , medicine , asthma , financial economics , economics
Ultraviolet derivative spectrometry has been proposed for the analysis of salbutamol and related impurities. The assay of salbutamol aldehyde, 5‐formyl‐saligenin, and salbutamol ketone was performed in sodium hydroxide 0.1 mol/l solutions, using first and second derivative spectra. The method has been applied for the assay of related impurities of commercial samples of salbutamol sulfate.