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Antiulcer Effect of the N ‐and O‐β‐D‐Glucopyranosides of 5‐Aminosalicylic Acid
Author(s) -
Sztaricskai Ferenc,
Takács Ildikó E.,
Pusztai Ferenc,
Szabó Gábor,
Csípõ István
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19999)332:9<321::aid-ardp321>3.0.co;2-a
Subject(s) - chemistry , aminosalicylic acid , antiulcer drug , stereochemistry , pharmacology , medicine , drug
Starting from methyl 5‐nitrosalicylate ( 20 ) the N ‐ and O ‐β‐glucopyranosyl derivatives ( 24, 28 ) of 5‐aminosalicylic acid were prepared. The LD 50 values of these compounds were determined on mice, and the inhibitory effect of 24 (0.83 mmol/kg) and 28 (1.2 mmol/kg) on gastric ulcer on rats, induced by indomethacin was investigated.