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Synthesis and Inhibitory Effect on Platelet Aggregation and Antihypertensive Activity of 1‐Hydroxy‐2,5‐dihydro‐1 H ‐imidazole‐2‐ carboxylic Acid 3‐Oxides, 1,3‐Dihydroxyimidazolidine‐2‐carboxylic Acids, and 1,4‐Dihydroxy‐2,3‐piperazinediones
Author(s) -
Tikhonov Aleksei Ya.,
Mazhukin Dmitrii G.,
Grigor′eva Larisa N.,
Khlestkin Vadim K.,
Voinova Natal′ya N.,
Syropyatov Boris Ya.,
Shirinkina Svetlana S.,
Volodarsky Leonid B.
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19999)332:9<305::aid-ardp305>3.0.co;2-2
Subject(s) - glyoxylic acid , chemistry , carboxylic acid , imidazole , pyruvic acid , stereochemistry , medicinal chemistry , organic chemistry
The reaction of 1,2‐hydroxylamino‐oximes 1 with pyruvic or glyoxylic acid and of 1,2‐bishydroxylamines 4 with glyoxylic acid resulted in 2,5‐dihydro‐1 H ‐imidazole‐2‐carboxylic acid 3‐oxides 2 and 2‐imidazolidinecarboxylic acids 5 , respectively. It was found that hydroxylamino acids 2 and 1,4‐dihydroxy‐2,3‐piperazinediones 7 showed marked inhibitory effect on platelet aggregation. 1‐Hydroxy‐2‐methyl‐1,5,6,7,8,8a‐hexahydro‐2 H ,4 H ‐cycloheptimidazole‐2‐carboxylic acid 3‐oxide 2e exhibited antihypertensive activity.