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Synthesis, Toxicological, and Pharmacological Assessment of Some Oximes and Aldehyde Condensation Products of 4‐Hydroxycoumarin
Author(s) -
Manolov Ilia,
Danchev Nicolay D.
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19997)332:7<243::aid-ardp243>3.0.co;2-2
Subject(s) - chemistry , 4 hydroxycoumarin , acute toxicity , warfarin , anticoagulant , oxime , pharmacology , aldehyde , in vivo , toxicity , organic chemistry , medicine , surgery , catalysis , microbiology and biotechnology , biology , atrial fibrillation
The synthesis of condensation products of 4‐hydroxycoumarin and nitro‐substituted aromatic aldehydes as well as oximes of drugs with anticoagulant activity is described. The acute toxicity of the compounds was studied in mice by oral and intraperitoneal administration. A comparative pharmacological study of the in vivo anticoagulant effects of Warfarin derivatives showed that the new compounds have different anticoagulant activity. 4‐Hydroxy‐3‐[1‐(4‐chlorophenyl)‐3‐oxobutyl]‐2 H ‐1‐benzopyran‐2‐one, oxime 3 showed anticoagulant effect similar to Warfarin and Coumachlor, but its acute toxicity was higher than that of the reference drugs.