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3‐Amino‐ and 5‐Aminopyrazoles with Anticonvulsant Activity
Author(s) -
Lankau HansJoachim,
Menzer Manfred,
Rostock Angelika,
Arnold Thomas,
Rundfeldt Chris,
Unverferth Klaus
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19996)332:6<219::aid-ardp219>3.0.co;2-t
Subject(s) - anticonvulsant , chemistry , pyrazole , sodium , chemical synthesis , pharmacology , combinatorial chemistry , medicinal chemistry , epilepsy , organic chemistry , biochemistry , in vitro , medicine , psychiatry
New 3‐amino‐ and 5‐aminopyrazoles were synthesised. 3‐Aminopyrazoles exert a strong anticonvulsant effect. 4‐Chlorophenyl‐3‐( morpholin‐4‐yl)‐1 H ‐pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.