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Synthesis and Analgesic Activity of Some Condensed Analogs of Anpirtoline
Author(s) -
Rádl Stanislav,
Kovárová Lenka,
Hezky Petr,
Vosátka Václav,
Königová Otylie,
Proška Jan,
Krejcí Ivan
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19996)332:6<208::aid-ardp208>3.0.co;2-0
Subject(s) - chemistry , analgesic , isoquinoline , quinazoline , phthalazine , quinoline , tramadol , pyridine , acetic acid , pharmacology , stereochemistry , medicinal chemistry , organic chemistry , medicine
New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, isoquinoline, quinazoline, and phthalazine nuclei, have been synthesized. Their receptor binding profiles (5‐HT 1A , 5‐HT 1B ) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 7d, 8b, 8c, and 8e are at least comparable to that of the clinically used drugs flupirtine and tramadol under the same conditions.