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Determination of Aminoglutethimide Enantiomers as Dansyl Derivative in Human Plasma by HPLC with Fluorescence Detection
Author(s) -
AboulEnein Hassan Y.,
Özkirimli Sumru,
Apak T. Idil
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19994)332:4<145::aid-ardp145>3.0.co;2-4
Subject(s) - aminoglutethimide , chemistry , enantiomer , chromatography , high performance liquid chromatography , detection limit , fluorescence , fluorescence spectroscopy , derivative (finance) , stereochemistry , medicine , physics , cancer , quantum mechanics , breast cancer , aromatase , financial economics , economics
Determination of aminoglutethimide enantiomers as a dansyl derivative in plasma by HPLC has been achieved using cellulose tris(3,5‐dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD, and a mobile phase consisted of ethanol‐cyclo‐hexane‐methanol (95:5:2 v/v/v ). The limit of detection for each enantiomer of aminoglutethimide using fluorescence detector was 20 ng ml ‐1 .