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Synthesis of Ginseng Diyne Analogues and Their Antiproliferative Activity against L1210 Cells
Author(s) -
ShinIl Kim,
YouHui Lee,
ByungZun Ahn
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19994)332:4<133::aid-ardp133>3.0.co;2-g
Subject(s) - moiety , ginseng , chemistry , l1210 cells , stereochemistry , biological activity , structure–activity relationship , cytotoxicity , biochemistry , in vitro , medicine , alternative medicine , pathology
Some analogues of Ginseng diyne were synthesized and tested for antiproliferative activity against L1210 cells. The epoxy moiety of panaxydol, isolated from the root of Panax ginseng , proved to be in the cis ‐form on comparison with synthetic specimens. Analysis of structure‐activity relationship revealed that the presence of the heptadec‐1‐ene‐4,6‐diyn‐3‐ol moiety in the structure of the analogues was essential for their antiproliferative activity and that the epoxy and alkyl groups in the structure contributed to enhancement of the antiproliferative activity.