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Synthesis and Pharmacological Activities of Novel 3‐(Isoxazol‐3‐yl)‐quinazolin‐4(3 H )‐one Derivatives
Author(s) -
Daidone Giuseppe,
Raffa Demetrio,
Maggio Benedetta,
Plescia Fabiana,
Cutuli Vincenza Maria Catena,
Mangano Nunzio Guido,
Caruso Antonina
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19993)332:2<50::aid-ardp50>3.0.co;2-s
Subject(s) - chemistry , phenylbutazone , analgesic , acetic acid , pharmacology , peritonitis , acute toxicity , toxicity , organic chemistry , medicine
Several new 3‐(isoxazol‐3‐yl)‐quinazolin‐4(3 H )‐one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.