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Synthesis of 2‐[2‐(1‐Imidazolyl)ethyl]‐4‐phenylcycloalka[ g ]phthalazin‐1(2 H )‐ones as Thromboxane A 2 Synthase Inhibitors
Author(s) -
Haider Norbert,
Hartmann Rolf W.,
Steinwender Andreas
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199911)332:11<408::aid-ardp408>3.0.co;2-p
Subject(s) - thromboxane a synthase , chemistry , atp synthase , stereochemistry , thromboxane a2 , pharmacology , enzyme , biochemistry , receptor , medicine
A series of 2‐[2‐(1‐imidazolyl)ethyl]‐4‐phenylcycloalka[ g ]phthal‐azin‐1(2 H )‐ones ( 3a—d ) with variable cycloalkene ring size was prepared and tested in vitro for thromboxane A 2 synthase inhibitory activity.