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Development of Sustained‐Release Ibuprofen Microspheres Using Solvent Evaporation Technique
Author(s) -
Arida Adi I.,
Amro Bassam,
Jaghbir Madi,
ElAlem Malek,
Sabri Rebal,
AbuZeid Rula
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199911)332:11<405::aid-ardp405>3.0.co;2-0
Subject(s) - ibuprofen , polyethylene glycol , peg ratio , particle size , chemistry , emulsion , pulmonary surfactant , polymer , microsphere , solvent , evaporation , chemical engineering , ethyl cellulose , chromatography , organic chemistry , medicine , biochemistry , physics , finance , engineering , economics , pharmacology , thermodynamics
The emulsion‐solvent evaporation method was used for the preparation of ibuprofen microspheres using cellulose acetate polymer. Polyethylene glycol was used as a surfactant to improve the release properties of ibuprofen at a drug to polymer to PEG ratio of 1:2:1. The microspheres were prepared at three different speeds (800, 1200, 1600 rpm), and were characterized with regard to their surface morphology, percentage yield, average drug content, particle size distribution, and release properties in phosphate buffer pH 6.9 at 37 °C. The particles decreased with increasing stirrer speed. The formed ibuprofen microspheres were subjected to accelerated stability studies for 3 months, and the effect of the storage time on the different characteristics was studied. The physical properties and release profiles of ibuprofen microspheres did not change after storage under accelerated stability conditions for 3 months.