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Synthesis and Analgesic Activity of Some Deaza Derivatives of Anpirtoline
Author(s) -
Rádl Stanislav,
Hezky Petr,
Proška Jan,
Krejcí Ivan
Publication year - 1999
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19991)332:1<13::aid-ardp13>3.0.co;2-l
Subject(s) - analgesic , chemistry , hot plate , acetic acid , stereochemistry , chemical synthesis , pharmacology , biochemistry , biology , in vitro , mechanical engineering , engineering
New deaza derivatives of anpirtoline have been synthesized by three different methods. Their receptor binding profiles (5‐HT 1A , 5‐HT 1B ) and analgesic activity (hot plate, acetic acid induced writhing) have been studied.