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Synthesis and Antimicrobial Activity of a Dihydroampicillin and a Dihydrocephalexin
Author(s) -
Hashem A. I.,
Shaban M. E.,
AbdelAziz R.,
AbdelNasser G.
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19989)331:9<294::aid-ardp294>3.0.co;2-f
Subject(s) - antimicrobial , chemistry , stereochemistry , traditional medicine , medicine , organic chemistry
A dihydroampicillin ( 3 ) and a dihydrocephalexin ( 4 ) have been synthesized by condensing α‐(cyclohexa‐1,3‐dienyl)glycyl chloride with 6‐aminopenicillanic acid ( 1 ) and 7‐deacetoxycephalo‐sporanic acid ( 2 ) respectively. The two antibiotics obtained show enhanced antimicrobial activity towards certain bacterial strains compared with ampicillin and cephalexin.