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Synthesis and Pharmacological Evaluation of N ‐Phenyl‐ N′ ‐[1‐[3‐(1‐aryl‐4‐piperazinyl)propan‐2‐ol]]ureas
Author(s) -
Bosc Jean Jacques,
Jarry Christian
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(19989)331:9<291::aid-ardp291>3.0.co;2-r
Subject(s) - aryl , chemistry , stereochemistry , chemical synthesis , analgesic , combinatorial chemistry , organic chemistry , pharmacology , in vitro , medicine , alkyl , biochemistry
N‐Phenyl‐ N ’‐[1‐[3‐(1‐aryl‐4‐piperazinyl)propan‐2‐ol]]ureas ( 3 ) were synthesized from the 3‐phenylcarbamoyl‐5‐[(1‐aryl‐4‐piperazinyl)methyl]‐2‐iminooxazolidines ( 1 ) via the corresponding 2‐oxazolidinones ( 2 ). The prepared compounds were screened for their antiallergic and analgesic activities.