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Cytotoxic Effects of Quinoxaline Derivatives on Human Cancer Cell Lines
Author(s) -
Yoo HeeWon,
Lee YunSil,
Eun Suh Myung,
Kim Dong Jin,
Park Sang Woo
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199810)331:10<331::aid-ardp331>3.0.co;2-i
Subject(s) - quinoxaline , chemistry , cytotoxic t cell , mtt assay , cell culture , cytotoxicity , in vitro , ic50 , adenocarcinoma , pyrazine , cell , cancer , stereochemistry , biochemistry , biology , medicine , organic chemistry , genetics
The cytotoxicities of 6,7‐modified‐5,8‐quinoxalinedione derivatives and heterocyclic quinoxaline derivatives containing nitrogen, sulfur, and oxygen on human lung adenocarcinoma cell (PC 14), human gastric adenocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 205) were examined in vitro using MTT assay. Pyrido[1,2‐α]imidazo[4,5‐ g ]quinoxaline‐6,11‐dione ( 10 ) was markedly cytotoxic against MKN 45 compared with adriamycin and cis ‐platin used as anticancer drugs. The IC 50 value of compound 10 was 0.073 μM while those of adriamycin and cis ‐platin were 0.12 μM and 2.67 μM, respectively.