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Synthesis, Structure, and Biological Activities of Some N ‐(4,5‐Dihydro‐1 H ‐imidazol‐2‐yl)‐l,3‐dihydrobenzimidazole Derivatives
Author(s) -
Sączewski Franciszek,
Debowski Tomasz,
Petrusewicz Jacek,
Trzeciak Henryk,
Krzystanek Ewa,
Krzystanek Marak,
Gdaniec Maria,
Novakowska Emilia
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199807)331:7/8<241::aid-ardp241>3.0.co;2-6
Subject(s) - chemistry , stereochemistry , biological activity , chemical synthesis , pharmacology , platelet aggregation , platelet , blood pressure , in vitro , biochemistry , medicine
A series of novel N ‐(4,5‐dihydroimidazol‐2‐yl)‐1,3‐dihydrobenzimidazole derivatives 2a–d , 3a–d and 4a–p were prepared and their structure was determined by IR and NMR spectroscopic data as well as X‐ray analysis of carbonitrile 2a . The compounds were studied as potential inhibitors of the human blood platelet aggregation induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intravenous administration to normotensive rats.