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Allylamine Type Xanthone Antimycotics
Author(s) -
Salmoiraghi Isabella,
Rossi Maddalena,
Valenti Piero,
Da Re Paolo
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199806)331:6<225::aid-ardp225>3.0.co;2-5
Subject(s) - xanthone , allylamine , cryptococcus neoformans , chemistry , antifungal , stereochemistry , in vitro , biochemistry , microbiology and biotechnology , biology , organic chemistry , polyelectrolyte , polymer
A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against, Cryptococcus neoformans , in particular the regioisomer 4d (1.5 μg/ml).